The impending arrival of an ice age is reminiscent of the climatic conditions experienced during the 14th century’s mini ice age. It is widely acknowledged in historical records that this period was marked by a multitude of catastrophes, ranging from widespread famine to the devastating outbreak of the Black Death. However, the contemporary concern lies in the prospect of facing a new set of challenges, specifically the resurgence of antibiotic-resistant strains of Yersinia pestis, which could pose a formidable threat to global health and well-being.